Hif1atm1.1Stom
Targeted Allele Detail
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| Symbol: |
Hif1atm1.1Stom |
| Name: |
hypoxia inducible factor 1, alpha subunit; targeted mutation 1.1, Shuhei Tomita |
| MGI ID: |
MGI:2677899 |
| Synonyms: |
Hif-1alphadelta |
| Gene: |
Hif1a Location: Chr12:73948186-73994304 bp, + strand Genetic Position: Chr12, 31.99 cM
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| Alliance: |
Hif1atm1.1Stom page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:85763
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
Not Specified
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Exons 13, 14, and 15 were deleted by cre-mediated recombination of flanking loxP sites. The deleted region encoded the C-terminal transactivation domain that is involved in response to hypoxia, Cri2 recruitment, and efficient nuclear localization. Though a truncated protein consisting was detected, it was reported to be non-functional.
(J:85763)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Hif1a Mutation: |
50 strains or lines available
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| Original: |
J:85763 Tomita S, et al., Defective brain development in mice lacking the Hif-1alpha gene in neural cells. Mol Cell Biol. 2003 Oct;23(19):6739-49 |
| All: |
5 reference(s) |
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Analysis Tools
