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Cops3tm1Jrl
Targeted Allele Detail
Summary
Symbol: Cops3tm1Jrl
Name: COP9 signalosome subunit 3; targeted mutation 1, James R Lupski
MGI ID: MGI:2678261
Synonyms: Csn3-, Csn35'm
Gene: Cops3  Location: Chr11:59708621-59730664 bp, - strand  Genetic Position: Chr11, 37.8 cM, cytoband B2
Alliance: Cops3tm1Jrl page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:85760
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1b-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation details: A 5'HPRT minigene segment along with a neomycin resistance gene was inserted after exon 6 and was followed by a duplication of exons 3-6 with about 10kb of vector sequence. No protein product could be identified in homozygotes by western blot analysis. (J:85760)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 13 assay results
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cops3 Mutation:  26 strains or lines available
References
Original:  J:85760 Yan J, et al., COP9 signalosome subunit 3 is essential for maintenance of cell proliferation in the mouse embryonic epiblast. Mol Cell Biol. 2003 Oct;23(19):6798-808
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory