Impdh1tm1Bmi
Targeted Allele Detail
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| Symbol: |
Impdh1tm1Bmi |
| Name: |
inosine monophosphate dehydrogenase 1; targeted mutation 1, Beverly S Mitchell |
| MGI ID: |
MGI:2678364 |
| Synonyms: |
Impdh1-, IMPDH type I- |
| Gene: |
Impdh1 Location: Chr6:29200435-29216363 bp, - strand Genetic Position: Chr6, 12.36 cM, cytoband A3
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| Alliance: |
Impdh1tm1Bmi page
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A PGK-neomycin resistance gene was inserted in exon 9 together with a deletion of sequence at the end of the exon coding for amino acids 323-331. This eliminates the 2 amino acids lining the IMP binding pocket. No detectable mRNA transcripts are formed and Western blot analysis indicates that there is no gene product in thymus, lungs, or lymphocytes.
(J:85443)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Impdh1 Mutation: |
26 strains or lines available
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| Original: |
J:85443 Gu JJ, et al., Targeted disruption of the inosine 5'-monophosphate dehydrogenase type I gene in mice. Mol Cell Biol. 2003 Sep;23(18):6702-12 |
| All: |
4 reference(s) |
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Analysis Tools
