Pmaip1tm1Ttg
Targeted Allele Detail
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| Symbol: |
Pmaip1tm1Ttg |
| Name: |
phorbol-12-myristate-13-acetate-induced protein 1; targeted mutation 1, Tadatsugu Taniguchi |
| MGI ID: |
MGI:2678372 |
| Synonyms: |
Noxa- |
| Gene: |
Pmaip1 Location: Chr18:66591675-66598629 bp, + strand Genetic Position: Chr18, 39.52 cM, cytoband E1
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| Alliance: |
Pmaip1tm1Ttg page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:85569
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| Parent Cell Line: |
E14.1 (ES Cell)
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| Strain of Origin: |
129P2/OlaHsd
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A 2.4 kb genomic freagment encompassing exons 1 and 2 was replaced with a neomycin selection cassette inserted by homologous recombination. Neither transcript nor protein was detected by Northern and Western blot analysis of homozygous mutant MEFs treated with adriamycin, which stimulates expression in wild-type MEFs.
(J:85569)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Original: |
J:85569 Shibue T, et al., Integral role of Noxa in p53-mediated apoptotic response. Genes Dev. 2003 Sep 15;17(18):2233-8 |
| All: |
5 reference(s) |
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Analysis Tools
