Ikbkbtm1Cgn
Targeted Allele Detail
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| Symbol: |
Ikbkbtm1Cgn |
| Name: |
inhibitor of kappaB kinase beta; targeted mutation 1, University of Cologne |
| MGI ID: |
MGI:2678815 |
| Synonyms: |
Ikk2DeltaKFL |
| Gene: |
Ikbkb Location: Chr8:23149228-23196605 bp, - strand Genetic Position: Chr8, 11.42 cM, cytoband A3-A4
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| Alliance: |
Ikbkbtm1Cgn page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:79132
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| Parent Cell Line: |
Bruce 4 (ES Cell)
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| Strain of Origin: |
B6.Cg-Thy1a
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| Allele Type: |
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Targeted (Conditional ready, No functional change) |
| Mutation: |
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Insertion
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Mutation details: Single loxP sites flank exon 7. The floxed exon encodes amino acids 160 through 189, including serines 177 and 181, two residues of the activation loop that are essential for kinase activity. Excision of the floxed fragment results in splicing between exons 6 and 8, producing a protein that lacks kinase activity but that is incorporated into the Ikbk complex.
(J:85810)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Ikbkb Mutation: |
56 strains or lines available
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| Original: |
J:79132 Pasparakis M, et al., IkappaB kinase signaling is essential for maintenance of mature B cells. J Exp Med. 2002 Sep 16;196(6):743-52 |
| All: |
11 reference(s) |
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Analysis Tools
