Fcgr1tm1Hoga
Targeted Allele Detail
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| Symbol: |
Fcgr1tm1Hoga |
| Name: |
Fc receptor, IgG, high affinity I; targeted mutation 1, P Mark Hogarth |
| MGI ID: |
MGI:2679238 |
| Synonyms: |
FcgammaRI-, FcRI- |
| Gene: |
Fcgr1 Location: Chr3:96190225-96201285 bp, - strand Genetic Position: Chr3, 41.72 cM
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| Alliance: |
Fcgr1tm1Hoga page
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A 400 bp fragment was deleted from the 5' portion of the gene. This deleted sequence included the promoter and the transcription and translation start sites. In addition a neo cassette was inserted into the second leader exon, disrupting the leader sequence and generating a premature stop codon immediately downstream of exon 2. Transcript was undetected by Northern blot analysis of homozygous bone marrow macrophages (BMM) even after stimulation with interferon gamma. Surface protein was undetected via ligand or antibody binding.
(J:86281)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Fcgr1 Mutation: |
35 strains or lines available
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| Original: |
J:86280 Gavin AL, et al., Identification of the mouse IgG3 receptor: implications for antibody effector function at the interface between innate and adaptive immunity. J Immunol. 1998 Jan 1;160(1):20-3 |
| All: |
36 reference(s) |
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Analysis Tools
