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Crb2 Gene Detail
Summary
  • Symbol
    Crb2
  • Name
    crumbs family member 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2679260
    NCBI Gene: 241324
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:37666261-37689115 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 24.19 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    521 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2679260
 protein coding gene Chr2:37666238-37689115 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025699
 protein coding gene Chr2:36494275-36518341 (+)
A/J MGP_AJ_G0025676
 protein coding gene Chr2:35001506-35024385 (+)
AKR/J MGP_AKRJ_G0025646
 protein coding gene Chr2:36158388-36181199 (+)
BALB/cJ MGP_BALBcJ_G0025671
 protein coding gene Chr2:35058716-35081902 (+)
C3H/HeJ MGP_C3HHeJ_G0025432
 protein coding gene Chr2:36076431-36101884 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026117
 protein coding gene Chr2:37529735-37554053 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023522
 protein coding gene Chr2:33665407-33688624 (+)
CAST/EiJ MGP_CASTEiJ_G0024895
 protein coding gene Chr2:35996889-36025237 (+)
CBA/J MGP_CBAJ_G0025411
 protein coding gene Chr2:38935013-38959968 (+)
DBA/2J MGP_DBA2J_G0025543
 protein coding gene Chr2:34744019-34766972 (+)
FVB/NJ MGP_FVBNJ_G0025505
 protein coding gene Chr2:34622336-34645674 (+)
LP/J MGP_LPJ_G0025630
 protein coding gene Chr2:36388051-36410901 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025536
 protein coding gene Chr2:38539509-38563017 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026175
 protein coding gene Chr2:36040012-36066428 (+)
PWK/PhJ MGP_PWKPhJ_G0024637
 protein coding gene Chr2:34641173-34664106 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024442
 protein coding gene Chr2:36161687-36185393 (+)
WSB/EiJ MGP_WSBEiJ_G0024963
 protein coding gene Chr2:36224366-36247187 (+)



Homology
more
  • Human Ortholog
    CRB2, crumbs cell polarity complex component 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CRB2, crumbs cell polarity complex component 2
  • Synonyms
    FSGS9, VMCKD
  • Links
    NCBI Gene ID: 286204
    neXtProt AC: NX_Q5IJ48
    UniProt: Q5IJ48

  • Chr Location
    9q33.3; chr9:123354065-123380326 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Crb2 mouse models; 2 with human CRB2 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    61 phenotypes from 3 alleles in 6 genetic backgrounds
    19 phenotypes from multigenic genotypes
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene causes severe gastrulation defects, impaired somitogenesis and organogenesis. and complete embryonic death by E12.5. Several organ primordia, including neuroepithelium, gut, and heart, fail to form properly.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    731
  • Tissues
    14
  • cDNA Data
    30
  • Literature Summary
    20
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000035403 Ensembl Gene Model | MGI Sequence Detail 22855 C57BL/6J ±  kb
    transcript ENSMUST00000050372 Ensembl | MGI Sequence Detail 6372 Not Applicable  
    polypeptide ENSMUSP00000058007 Ensembl | MGI Sequence Detail 1282 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000005849 protein crumbs homolog 2
      (term hierarchy)
    • InterPro Domains
      IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
      IPR018097 EGF-like calcium-binding, conserved site
      IPR001881 EGF-like calcium-binding domain
      IPR013032 EGF-like, conserved site
      IPR000742 EGF-like domain
      IPR000152 EGF-type aspartate/asparagine hydroxylation site
      IPR009030 Growth factor receptor cysteine-rich domain superfamily
      IPR001791 Laminin G domain
      IPR050372 Neurexin-related cell adhesion and synaptic protein
      IPR051022 Notch Signaling and Cell Fate Determination
    • GlyGen
      Q80YA8 13 sites, 2 N-linked glycans (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 31
      cDNA 30
      Primer pair 1

      Microarray probesets 1
    References
    more
    • Summaries
      All 69
      Developmental Gene Expression 20
      Diseases 3
      Gene Ontology 13
      Phenotypes 27
    • Earliest
      J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
    • Latest
      J:354796 Cho SH, et al., Perturbed cell cycle phase-dependent positioning and nuclear migration of retinal progenitors along the apico-basal axis underlie global retinal disorganization in the LCA8-like mouse model. Dev Biol. 2024 Sep 14;517:39-54
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory