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Rgma Gene Detail
Summary
  • Symbol
    Rgma
  • Name
    repulsive guidance molecule family member A
  • Synonyms
    MGC:38550, MGC:69915, RGM domain family, member A
  • Feature Type
    protein coding gene
  • IDs
    MGI:2679262
    NCBI Gene: 244058
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:73025268-73069647 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 41.85 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1249 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2679262
 protein coding gene Chr7:73025257-73069647 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032368
 protein coding gene Chr7:74927994-74973760 (+)
A/J MGP_AJ_G0032347
 protein coding gene Chr7:73245068-73289433 (+)
AKR/J MGP_AKRJ_G0032283
 protein coding gene Chr7:74779368-74822968 (+)
BALB/cJ MGP_BALBcJ_G0032359
 protein coding gene Chr7:73002353-73044940 (+)
C3H/HeJ MGP_C3HHeJ_G0032072
 protein coding gene Chr7:75550057-75599572 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032851
 protein coding gene Chr7:78029336-78075261 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029859
 protein coding gene Chr7:75887168-75931138 (+)
CAST/EiJ MGP_CASTEiJ_G0031400
 protein coding gene Chr7:66364485-66413169 (+)
CBA/J MGP_CBAJ_G0032038
 protein coding gene Chr7:80558713-80614368 (+)
DBA/2J MGP_DBA2J_G0032193
 protein coding gene Chr7:71913290-71955196 (+)
FVB/NJ MGP_FVBNJ_G0032148
 protein coding gene Chr7:71967455-72009943 (+)
LP/J MGP_LPJ_G0032274
 protein coding gene Chr7:76154780-76201413 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032185
 protein coding gene Chr7:80716573-80759158 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032869
 protein coding gene Chr7:74248353-74294556 (+)
PWK/PhJ MGP_PWKPhJ_G0031120
 protein coding gene Chr7:65054515-65101077 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030961
 protein coding gene Chr7:61314772-61364687 (+)
WSB/EiJ MGP_WSBEiJ_G0031518
 protein coding gene Chr7:74591555-74637331 (+)



Homology
more
  • Human Ortholog
    RGMA, repulsive guidance molecule BMP co-receptor a
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RGMA, repulsive guidance molecule BMP co-receptor a
  • Synonyms
    RGM
  • Links
    NCBI Gene ID: 56963
    neXtProt AC: NX_Q96B86
    UniProt: Q96B86

  • Chr Location
    15q26.1; chr15:93035271-93089211 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human RGMA associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Inactivation of this locus results in impaired cephalic closure and subsequent exencephaly, both with incomplete penetrance. The retinal topography of the visual system is normal in homozygous mutant mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1310
  • Tissues
    218
  • cDNA Data
    54
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 244058 NCBI Gene Model | MGI Sequence Detail 44380 C57BL/6J ±  kb
    transcript NM_177740 RefSeq | MGI Sequence Detail 3586 C57BL/6  
    polypeptide Q6PCX7 UniProt | EBI | MGI Sequence Detail 454 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 62
      cDNA 55
      Primer pair 3
      Other 4

      Microarray probesets 2
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 18
      Gene Ontology 10
      Phenotypes 17
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:358244 Shimizu M, et al., RGMa collapses the neuronal actin barrier against disease-implicated protein and exacerbates ALS. Sci Adv. 2023 Nov 24;9(47):eadg3193
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory