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Satb2 Gene Detail
Summary
  • Symbol
    Satb2
  • Name
    special AT-rich sequence binding protein 2
  • Synonyms
    BAP002, mKIAA1034
  • Feature Type
    protein coding gene
  • IDs
    MGI:2679336
    NCBI Gene: 212712
  • Alliance
    gene page
  • Transcription Start Sites
    22 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:56833140-57017809 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 28.72 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    3963 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2679336
 protein coding gene Chr1:56833140-57019350 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016038
 protein coding gene Chr1:56581596-56772993 (-)
A/J MGP_AJ_G0016021
 protein coding gene Chr1:54617326-54801921 (-)
AKR/J MGP_AKRJ_G0015977
 protein coding gene Chr1:56069043-56258696 (-)
BALB/cJ MGP_BALBcJ_G0015976
 protein coding gene Chr1:54645669-54835892 (-)
C3H/HeJ MGP_C3HHeJ_G0015808
 protein coding gene Chr1:56360318-56553667 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016429
 protein coding gene Chr1:58926675-59126707 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014150
 protein coding gene Chr1:50595343-50777698 (-)
CAST/EiJ MGP_CASTEiJ_G0015390
 protein coding gene Chr1:55607785-55819762 (-)
CBA/J MGP_CBAJ_G0015780
 protein coding gene Chr1:60608616-60811321 (-)
DBA/2J MGP_DBA2J_G0015881
 protein coding gene Chr1:54032246-54218615 (-)
FVB/NJ MGP_FVBNJ_G0015883
 protein coding gene Chr1:53360770-53545256 (-)
LP/J MGP_LPJ_G0015953
 protein coding gene Chr1:57474595-57667457 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015903
 protein coding gene Chr1:63672594-63871175 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016476
 protein coding gene Chr1:56063283-56257931 (-)
PWK/PhJ MGP_PWKPhJ_G0015176
 protein coding gene Chr1:53354443-53545240 (-)
SPRET/EiJ MGP_SPRETEiJ_G0014957
 protein coding gene Chr1:55646951-55837541 (-)
WSB/EiJ MGP_WSBEiJ_G0015453
 protein coding gene Chr1:55728307-55921525 (-)



Homology
more
  • Human Ortholog
    SATB2, SATB homeobox 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SATB2, SATB homeobox 2
  • Synonyms
    C2DELq32q33, DEL2Q32Q33, GLSS
  • Links
    NCBI Gene ID: 23314
    neXtProt AC: NX_Q9UPW6
    UniProt: Q9UPW6

  • Chr Location
    2q33.1; chr2:199269500-199471266 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Satb2 mouse models; 1 with human SATB2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    54 phenotypes from 5 alleles in 5 genetic backgrounds
    6 phenotypes from multigenic genotypes
    57 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene causes complete perinatal lethality and craniofacial anomalies, such as cleft palate, micrognathia, microcephaly, decreased tongue size, absent incisors and nasal capsule hypoplasia, and leads to short limbs and defects in osteoblast differentiation and function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    44
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1493
  • Tissues
    224
  • cDNA Data
    32
  • Literature Summary
    378
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038331 Ensembl Gene Model | MGI Sequence Detail 184670 C57BL/6J ±  kb
    transcript ENSMUST00000114415 Ensembl | MGI Sequence Detail 5805 Not Applicable  
    polypeptide ENSMUSP00000110057 Ensembl | MGI Sequence Detail 733 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 44
      cDNA 32
      Primer pair 10
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:5425477
    References
    more
    • Summaries
      All 447
      Developmental Gene Expression 378
      Diseases 1
      Gene Ontology 13
      Phenotypes 57
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:354454 De Vincenti AP, et al., Lrig1 regulates cell fate specification of glutamatergic neurons via FGF-driven Jak2/Stat3 signaling in cortical progenitors. Development. 2024 Sep 1;151(17):dev202879
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory