Smad5<tm1.1Huy> Targeted Allele Detail MGI Mouse (MGI:2679443)

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Smad5^tm1.1Huy
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Smad5^tm1.1Huy
Name:	SMAD family member 5; targeted mutation 1.1, Danny Huylebroeck
MGI ID:	MGI:2679443
Synonyms:	Smad5^fldeltaE2
Gene:	Smad5 Location: Chr13:56850823-56890190 bp, + strand Genetic Position: Chr13, 30.12 cM
Alliance:	Smad5^tm1.1Huy page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:86157
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: Exon 2 was deleted via cre mediated recombination, leaving a single loxP site in its place. Exon 2 contains the translational start codon and approximately one-third of the protein coding sequence. (J:86157)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Smad5 Mutation:	23 strains or lines available

References

Original:	J:86157 Umans L, et al., Generation of a floxed allele of Smad5 for cre-mediated conditional knockout in the mouse. Genesis. 2003 Sep;37(1):5-11
All:	3 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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