Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | Notes | References

Symbol:	Slit3Gt(OST106158)Lex
Name:	slit guidance ligand 3; gene trap OST106158, Lexicon Genetics
MGI ID:	MGI:2679499
Synonyms:	Slit3Gt1Hhu
Gene:	Slit3  Location: Chr11:35012283-35599334 bp, + strand  Genetic Position: Chr11, 20.29 cM, cytoband A5
Alliance:	Slit3Gt(OST106158)Lex page

Mutant Cell Line:	OST106158
Germline Transmission:	Earliest citation of germline transmission: J:86149
Parent Cell Line:	Lex-1 (ES Cell)
Strain of Origin:	129S5/SvEvBrd
Project Collection:	Lexicon

Allele Type:    Gene trapped (Null/knockout, Reporter) Mutation:    Insertion of gene trap vector   Mutation details: The endogenous locus was disrupted by gene trap mutation. RT-PCR analysis of homozygous mutant mice indicated transcript levels were reduced to less than 1.5% of those of wild-type mice. (J:86149) Sequence Tags:  Sequence tag details (1 tag) Tag ID GenBank ID Method Tag Location (trapped strand)* Select OST106158 CG527790 (MGI Seq Detail) 3' RACE Chr11:35435575-35461546 bp (+) * GRCm39 (strand of gene trap mutagenesis) Selected Tags: download BLAST at NCBI Genome Context:  Genome Browser view of this mutation 28 gene trap insertions have trapped this gene View all gene trap sequence tags in this region

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

14 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Slit3 Mutation:	81 strains or lines available

Original:	J:86149 Liu J, et al., Congenital diaphragmatic hernia, kidney agenesis and cardiac defects associated with Slit3-deficiency in mice. Mech Dev. 2003 Sep;120(9):1059-70
All:	3 reference(s)