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Pak4tm1Amin
Targeted Allele Detail
Summary
Symbol: Pak4tm1Amin
Name: p21 (RAC1) activated kinase 4; targeted mutation 1, Audrey Minden
MGI ID: MGI:2679635
Synonyms: PAK4-
Gene: Pak4  Location: Chr7:28258244-28297609 bp, - strand  Genetic Position: Chr7, 16.84 cM
Alliance: Pak4tm1Amin page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:85954
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: Exon 1, containing the initiating methionine and the critical GTPase-binding domaain, was replaced with a PGK-neo cassette inserted by homologous recombination. Neither transcript nor protein was detected by Northern and Western blot analysis of homozygous mutant brain tissue. (J:85954)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 9 assay results
In Structures Affected by this Mutation: 9 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pak4 Mutation:  94 strains or lines available
Notes
ES cell line = D3 or E14.
References
Original:  J:85954 Qu J, et al., PAK4 kinase is essential for embryonic viability and for proper neuronal development. Mol Cell Biol. 2003 Oct;23(20):7122-33
All:  3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory