Slc9a9 MGI Mouse Gene Detail - MGI:2679732 - solute carrier family 9 (sodium/hydrogen exchanger), member 9

Symbol

Slc9a9
Name

solute carrier family 9 (sodium/hydrogen exchanger), member 9
Synonyms

5730527A11Rik, Nhe9

Feature Type

protein coding gene
IDs

MGI:2679732
NCBI Gene: 331004
Alliance

gene page
Transcription Start Sites

20 TSS

Sequence Map

Chr9:94551962-95112498 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 49.22 cM
Mapping Data

3 experiments

SNPs within 2kb

16381 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2679732	protein coding gene	Chr9:94551945-95112505 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035132	protein coding gene	Chr9:95794704-96361154 (+)
A/J	MGP_AJ_G0035113	protein coding gene	Chr9:92446464-93006768 (+)
AKR/J	MGP_AKRJ_G0035045	protein coding gene	Chr9:94651593-95235882 (+)
BALB/cJ	MGP_BALBcJ_G0035106	protein coding gene	Chr9:92128246-92683346 (+)
C3H/HeJ	MGP_C3HHeJ_G0034816	protein coding gene	Chr9:95105283-95682549 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035626	protein coding gene	Chr9:98521274-99102387 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032528	protein coding gene	Chr9:90744682-90747471 (+)
CAST/EiJ	MGP_CASTEiJ_G0034128	protein coding gene	Chr9:94837908-95409927 (+)
CBA/J	MGP_CBAJ_G0034784	protein coding gene	Chr9:101917468-102518414 (+)
DBA/2J	MGP_DBA2J_G0034946	protein coding gene	Chr9:91956592-92525895 (+)
FVB/NJ	MGP_FVBNJ_G0034894	protein coding gene	Chr9:90844384-91388134 (+)
LP/J	MGP_LPJ_G0035025	protein coding gene	Chr9:96016543-96589314 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034933	protein coding gene	Chr9:103960726-104553307 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035648	protein coding gene	Chr9:94891560-95469006 (+)
PWK/PhJ	MGP_PWKPhJ_G0033835	protein coding gene	Chr9:92116957-92678249 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033670	protein coding gene	Chr9:94869214-95468792 (+)
WSB/EiJ	MGP_WSBEiJ_G0034248	protein coding gene	Chr9:94763511-95338395 (+)

Human Ortholog

SLC9A9, solute carrier family 9 member A9

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC9A9, solute carrier family 9 member A9
Synonyms

AUTS16, NHE9
Links

HGNC:20653

NCBI Gene ID: 285195

neXtProt AC: NX_Q8IVB4

UniProt: Q8IVB4
Chr Location

3q24

MGI Vertebrate Homology

Slc9a9 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: SLC9A9
Gene Tree

Slc9a9

Diseases

1 with Slc9a9 mouse models; 1 with human SLC9A9 associations

Human Disease

Mouse Models

autism spectrum disorder

IDs

View 3 models

autistic disorder

IDs

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

3 with disease annotations

References

2 with disease annotations

less

Phenotype Summary

28 phenotypes from 4 alleles in 3 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

1
Targeted

7
Genomic Mutations

1 involving Slc9a9
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

42 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele display abnormal social and olfactory behavior, abnormal CNS synaptic transmission, impaired synaptic vesicle exocytosis, impaired presynaptic calcium entry, and decreased synaptic vescile pH.

less

All GO Annotations

25
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

875
Tissues

135
cDNA Data

29
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

less

All Sequences

40
RefSeq

2
UniProt

4
CCDS

CCDS40726.1

Ensembl

ENSMUSG00000031129 (Evidence)
NCBI Gene

331004

			Length	Strain/Species	Flank
genomic	ENSMUSG00000031129	Ensembl Gene Model \| MGI Sequence Detail	560537	C57BL/6J	± kb
transcript	ENSMUST00000033463	Ensembl \| MGI Sequence Detail	3468	Not Applicable
polypeptide	ENSMUSP00000033463	Ensembl \| MGI Sequence Detail	644	Not Applicable

less

UniProt

4 Sequences
Protein Ontology

PR:000015221 sodium/hydrogen exchanger 9

(term hierarchy)
InterPro Domains

IPR006153 Cation/H+ exchanger

IPR018422 Cation/H+ exchanger, CPA1 family

IPR004709 Na+/H+ exchanger

IPR002090 Sodium/hydrogen exchanger 6/7/9

less

All nucleic 31

cDNA 29

Primer pair 1

Other 1

Microarray probesets 6

less

MGI:1917898, MGI:2143161

Summaries

All 47

Developmental Gene Expression 8

Diseases 2

Gene Ontology 6

Phenotypes 12
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Slc9a9:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr86526	Chr9:94550919-94550935 (+)	-1,035 bp
Tssr86527	Chr9:94550948-94550965 (+)	-1,005 bp
Tssr86528	Chr9:94551672-94551694 (+)	-279 bp
Tssr86529	Chr9:94551929-94551981 (+)	-7 bp
Tssr86530	Chr9:94551998-94552009 (+)	42 bp
Tssr86531	Chr9:94552027-94552038 (+)	71 bp
Tssr86532	Chr9:94579021-94579039 (+)	27,068 bp
Tssr86533	Chr9:94595530-94595541 (+)	43,574 bp
Tssr86534	Chr9:94595612-94595626 (+)	43,657 bp
Tssr86535	Chr9:94625342-94625352 (+)	73,385 bp
Tssr86536	Chr9:94625581-94625598 (+)	73,628 bp
Tssr86537	Chr9:94652262-94652263 (+)	100,301 bp
Tssr86538	Chr9:94654877-94654882 (+)	102,918 bp
Tssr86539	Chr9:94828114-94828118 (+)	276,154 bp
Tssr86540	Chr9:94853869-94853875 (+)	301,910 bp
Tssr86541	Chr9:94910651-94910664 (+)	358,696 bp
Tssr86542	Chr9:94929912-94929915 (+)	377,952 bp
Tssr86543	Chr9:95044975-95044994 (+)	493,023 bp
Tssr86544	Chr9:95050254-95050274 (+)	498,302 bp
Tssr86545	Chr9:95074975-95074979 (+)	523,015 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24