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Cnga4tm1Reed
Targeted Allele Detail
Summary
Symbol: Cnga4tm1Reed
Name: cyclic nucleotide gated channel alpha 4; targeted mutation 1, Randall R Reed
MGI ID: MGI:2680015
Synonyms: CNGA4-
Gene: Cnga4  Location: Chr7:105053775-105057949 bp, + strand  Genetic Position: Chr7, 55.85 cM
Alliance: Cnga4tm1Reed page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:83225
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: Exons encoding the pore region, 2 transmembrane domains, and the cyclic nucleotide-binding region were replaced with a cassette containing tau-lacZ. A floxed region included in the targeting vector containing a partially deleted thymidine kinase gene and a neomycin resistant gene was excised via cre mediated recombination. Transcript was undetected by in situ hybridization of homozygous mutant olfactory receptor neurons. (J:83225)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cnga4 Mutation:  34 strains or lines available
References
Original:  J:83225 Munger SD, et al., Central role of the CNGA4 channel subunit in Ca2+-calmodulin-dependent odor adaptation. Science. 2001 Dec 7;294(5549):2172-5
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory