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Nod2tm1Pmu
Targeted Allele Detail
Summary
Symbol: Nod2tm1Pmu
Name: nucleotide-binding oligomerization domain containing 2; targeted mutation 1, Peter J Murray
MGI ID: MGI:2680581
Synonyms: Card15-, Nod2-
Gene: Nod2  Location: Chr8:89373943-89415102 bp, + strand  Genetic Position: Chr8, 43.51 cM, cytoband C3
Alliance: Nod2tm1Pmu page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:86264
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: The start codon, first CARD domain and half of the second CARD domain were eliminated by replacing the first exon with a PGK-neomycin resistance gene. RT-PCR on macrophage extracts demonstrated the absence of gene transcript. (J:86264)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 10 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nod2 Mutation:  63 strains or lines available
References
Original:  J:86264 Pauleau AL, et al., Role of nod2 in the response of macrophages to toll-like receptor agonists. Mol Cell Biol. 2003 Nov;23(21):7531-9
All:  13 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory