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Dicer1tm1Ghan
Targeted Allele Detail
Summary
Symbol: Dicer1tm1Ghan
Name: dicer 1, ribonuclease type III; targeted mutation 1, Gregory J Hannon
MGI ID: MGI:2681012
Gene: Dicer1  Location: Chr12:104654001-104718211 bp, - strand  Genetic Position: Chr12, 54.83 cM, cytoband E-F1
Alliance: Dicer1tm1Ghan page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:86391
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1b-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A PGK-neo cassete replaced exon 23 (previously called exon 21), which encodes the second RNase III domain. The splice donor and acceptor sites were left intact to further the potential of a null allele by permitting the incorporation of the neo cassette, and thus stop codons in all three reading frames, into the message. (J:86391)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 2 assay results
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dicer1 Mutation:  96 strains or lines available
References
Original:  J:86391 Bernstein E, et al., Dicer is essential for mouse development. Nat Genet. 2003 Nov;35(3):215-7
All:  6 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
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