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Keap1tm1Mym
Targeted Allele Detail
Summary
Symbol: Keap1tm1Mym
Name: kelch-like ECH-associated protein 1; targeted mutation 1, Masayuki Yamamoto
MGI ID: MGI:2681416
Synonyms: Keap1-
Gene: Keap1  Location: Chr9:21141026-21150628 bp, - strand  Genetic Position: Chr9, 7.74 cM, cytoband A3
Alliance: Keap1tm1Mym page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:86392
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Hypomorph, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: Sequence encoding 8 through 204 was replaced with a cassette containing nls-lacZ and neo. Transcript was undetected by Northern blot analysis of homozygous mutant mouse embryonic fibroblasts. Product from the inserted lacZ sequence was detected by Western blot. The allele is hypomorphic (J:182931). (J:86392)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 4 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 6 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Keap1 Mutation:  36 strains or lines available
References
Original:  J:86392 Wakabayashi N, et al., Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation. Nat Genet. 2003 Nov;35(3):238-45
All:  41 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory