Ar<tm1Ska> Targeted Allele Detail MGI Mouse (MGI:2681507)

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Ar^tm1Ska
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Summary

Symbol:	Ar^tm1Ska
Name:	androgen receptor; targeted mutation 1, Shigeaki Kato
MGI ID:	MGI:2681507
Synonyms:	ARKO
Gene:	Ar Location: ChrX:97192375-97366821 bp, + strand Genetic Position: ChrX, 42.82 cM
Alliance:	Ar^tm1Ska page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:85484
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A loxP site was inserted upstream of exon 1 and a floxed neomycin resistance cassette was introduced downstream. Cre mediated excision results in disruption of the gene. No mRNA transcripts were detected in the brain by Northern blot analysis and RT-PCR. Protein product was undetectable immunologically. This allele was generated from Ar^tm2Ska. (J:85484, J:88153)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Mice Carrying this Mutation:	1 assay results
In Structures Affected by this Mutation:	12 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Ar Mutation:	23 strains or lines available

References

Original:	J:85484 Matsumoto T, et al., Androgen receptor functions from reverse genetic models. J Steroid Biochem Mol Biol. 2003 Jun;85(2-5):95-9
All:	22 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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