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Artm1Ska
Targeted Allele Detail
Summary
Symbol: Artm1Ska
Name: androgen receptor; targeted mutation 1, Shigeaki Kato
MGI ID: MGI:2681507
Synonyms: ARKO
Gene: Ar  Location: ChrX:97192375-97366821 bp, + strand  Genetic Position: ChrX, 42.82 cM
Alliance: Artm1Ska page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:85484
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A loxP site was inserted upstream of exon 1 and a floxed neomycin resistance cassette was introduced downstream. Cre mediated excision results in disruption of the gene. No mRNA transcripts were detected in the brain by Northern blot analysis and RT-PCR. Protein product was undetectable immunologically. This allele was generated from Artm2Ska. (J:85484, J:88153)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 1 assay results
In Structures Affected by this Mutation: 12 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ar Mutation:  23 strains or lines available
References
Original:  J:85484 Matsumoto T, et al., Androgen receptor functions from reverse genetic models. J Steroid Biochem Mol Biol. 2003 Jun;85(2-5):95-9
All:  22 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory