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Ecsittm1Gho
Targeted Allele Detail
Summary
Symbol: Ecsittm1Gho
Name: ECSIT signalling integrator; targeted mutation 1, Sankar Ghosh
MGI ID: MGI:2683025
Synonyms: Ecsit-
Gene: Ecsit  Location: Chr9:21983542-21996734 bp, - strand  Genetic Position: Chr9, 8.23 cM, cytoband A4
Alliance: Ecsittm1Gho page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:86912
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A single loxP site remained in place of exons 2 through 8 after homologous recombination of floxed neo cassette and its subsequent cre-mediated excision. The deleted region included exons 2 through 5, which are common to the three known splice variants. Protein was undetected in homozygous mutant ES cells by Western blot analysis. (J:86912)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 23 assay results
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ecsit Mutation:  13 strains or lines available
References
Original:  J:86912 Xiao C, et al., Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis. Genes Dev. 2003 Dec 1;17(23):2933-49
All:  3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory