Wnk1<Gt(OST38262)Lex> Gene trapped Allele Detail MGI Mouse (MGI:2683145)

Wnk1^{Gt(OST38262)Lex}
Gene trapped Allele Detail

Summary

Symbol:	Wnk1^{Gt(OST38262)Lex}
Name:	WNK lysine deficient protein kinase 1; gene trap OST38262, Lexicon Genetics
MGI ID:	MGI:2683145
Synonyms:	Wnk1^-, Wnk1^{Gt(VICTR37)21Lex}
Gene:	Wnk1 Location: Chr6:119900930-120015633 bp, - strand Genetic Position: Chr6, 56.86 cM
Alliance:	Wnk1^{Gt(OST38262)Lex} page

Mutation
origin

Mutant Cell Line:	OST38262
Germline Transmission:	Earliest citation of germline transmission: J:86696
Parent Cell Line:	Lex-1 (ES Cell)
Strain of Origin:	129S5/SvEvBrd
Project Collection:	Lexicon

Mutation
description

Allele Type:

Gene trapped (Null/knockout, Reporter)

Mutation:

Insertion of gene trap vector

Mutation details: A gene trap vector (SA-Bgeo-pA-PGK-BTK-SD) inserted downstream of the first coding exon in intron 1. The amount of transcript in various heterozygous mutant organs was observed to be reduced by 41% to 57% relative to those of wild-type. (J:86696)

Sequence Tags:

Sequence tag details (1 tag)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	1 assay results
In Structures Affected by this Mutation:	15 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Wnk1 Mutation:	115 strains or lines available

References

Original:	J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
All:	5 reference(s)

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