St14tm1Bug
Targeted Allele Detail
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| Symbol: |
St14tm1Bug |
| Name: |
suppression of tumorigenicity 14 (colon carcinoma); targeted mutation 1, Thomas H Bugge |
| MGI ID: |
MGI:2683707 |
| Synonyms: |
Matriptase/MT-SP1 |
| Gene: |
St14 Location: Chr9:31000698-31043149 bp, - strand Genetic Position: Chr9, 16.61 cM
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| Alliance: |
St14tm1Bug page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:87125
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| Parent Cell Line: |
HM-1 (ES Cell)
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| Strain of Origin: |
129P2/OlaHsd-Hprt1b-m3
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A genomic fragment encompassing 350 bp of the putative intron 1 and the majority of the putative exon 2 was replaced with an hprt cassette inserted by homologous recombination. The deleted region encoded 19 of the 24 residues of the signal anchor required for membrane translocation. RT-PCR analysis identified mutant transcript in which the putative exon 1 spliced to the putative exon 3. This aberrant splice event results in a frameshift and ultimately a premature stop codon.
(J:87125)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any St14 Mutation: |
45 strains or lines available
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| Original: |
J:87125 List K, et al., Matriptase/MT-SP1 is required for postnatal survival, epidermal barrier function, hair follicle development, and thymic homeostasis. Oncogene. 2002 May 23;21(23):3765-79 |
| All: |
15 reference(s) |
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Analysis Tools
