About   Help   FAQ
Akap11 Gene Detail
Summary
  • Symbol
    Akap11
  • Name
    A kinase anchor protein 11
  • Synonyms
    6330501D17Rik, mKIAA0629
  • Feature Type
    protein coding gene
  • IDs
    MGI:2684060
    NCBI Gene: 219181
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:78729686-78774248 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 41.46 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    904 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2684060
 protein coding gene Chr14:78729686-78774306 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021590
 protein coding gene Chr14:73554431-73599241 (-)
A/J MGP_AJ_G0021548
 protein coding gene Chr14:71766354-71811684 (-)
AKR/J MGP_AKRJ_G0021525
 protein coding gene Chr14:73905010-73952301 (-)
BALB/cJ MGP_BALBcJ_G0021555
 protein coding gene Chr14:71592836-71638346 (-)
C3H/HeJ MGP_C3HHeJ_G0021332
 protein coding gene Chr14:73627357-73673036 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021995
 protein coding gene Chr14:76679929-76727874 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019533
 protein coding gene Chr14:69345100-69389778 (-)
CAST/EiJ MGP_CASTEiJ_G0020849
 protein coding gene Chr14:70418339-70463022 (-)
CBA/J MGP_CBAJ_G0021300
 protein coding gene Chr14:79130000-79175448 (-)
DBA/2J MGP_DBA2J_G0021423
 protein coding gene Chr14:71167819-71215245 (-)
FVB/NJ MGP_FVBNJ_G0021401
 protein coding gene Chr14:70507836-70552680 (-)
LP/J MGP_LPJ_G0021493
 protein coding gene Chr14:74662832-74710289 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021428
 protein coding gene Chr14:77791743-77840641 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022018
 protein coding gene Chr14:73194023-73238694 (-)
PWK/PhJ MGP_PWKPhJ_G0020592
 protein coding gene Chr14:67948852-67994015 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020429
 protein coding gene Chr14:69185565-69232969 (-)
WSB/EiJ MGP_WSBEiJ_G0020902
 protein coding gene Chr14:73538638-73586554 (-)



Homology
more
  • Human Ortholog
    AKAP11, A-kinase anchoring protein 11
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AKAP11, A-kinase anchoring protein 11
  • Synonyms
    AKAP-11, AKAP220, PPP1R44, PRKA11
  • Links
    NCBI Gene ID: 11215
    neXtProt AC: NX_Q9UKA4
    UniProt: Q9UKA4

  • Chr Location
    13q14.11; chr13:42271477-42323261 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show a reduction in body size, body length and tibia length, hypoactivity, slow movement and increased anxiety-related responses, and exhibit actin barrier defects in kidney collecting duct cells and increased urine osmolality in response to overhydration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    877
  • Tissues
    53
  • cDNA Data
    114
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022016 Ensembl Gene Model | MGI Sequence Detail 44563 C57BL/6J ±  kb
    transcript ENSMUST00000123853 Ensembl | MGI Sequence Detail 9364 Not Applicable  
    polypeptide ENSMUSP00000116015 Ensembl | MGI Sequence Detail 1894 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR018292 A-kinase anchor 110kDa, C-terminal
      IPR008382 SPHK1-interactor/A-kinase anchor 110kDa
    • GlyGen
      E9Q777 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 114
      cDNA 114

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2684926
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 16
    • Earliest
      J:86686 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Aug 31;10(4):167-80
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory