Med1tm1Mpk
Targeted Allele Detail
|
|
| Symbol: |
Med1tm1Mpk |
| Name: |
mediator complex subunit 1; targeted mutation 1, Malcom G Parker |
| MGI ID: |
MGI:2684189 |
| Synonyms: |
TRAP220con, TRAP220hyp |
| Gene: |
Med1 Location: Chr11:98042980-98084119 bp, - strand Genetic Position: Chr11, 61.75 cM, cytoband D
|
| Alliance: |
Med1tm1Mpk page
|
|
| Germline Transmission: |
Earliest citation of germline transmission:
J:86857
|
| Parent Cell Line: |
Not Specified (ES Cell)
|
| Strain of Origin: |
129P2/OlaHsd
|
|
| Allele Type: |
|
Targeted (Conditional ready, Hypomorph) |
| Mutation: |
|
Insertion
|
| |
|
Mutation details: A floxed neomycin resistance gene was placed in intron 2 while an additional loxP site was inserted in exon 1. The resulting construct was a hypomorph expressing 80% less mRNA than normal and with a comparable reduction in protein product. Transient transfection of properly targeted ES cells with a cre expression vector to remove neomycin but leaving exon 1 and 2 in place but flanked by loxP sites also resulted in a hypomorph with an identical phenotypic effect.
(J:86857)
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
|
|
| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
| Carrying any Med1 Mutation: |
83 strains or lines available
|
|
| Original: |
J:86857 Landles C, et al., The Thyroid Hormone Receptor-Associated Protein TRAP220 Is Required at Distinct Embryonic Stages in Placental, Cardiac, and Hepatic Development. Mol Endocrinol. 2003 Dec;17(12):2418-35 |
| All: |
1 reference(s) |
|
Analysis Tools
