Mbd4tm2Abc
Targeted Allele Detail
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| Symbol: |
Mbd4tm2Abc |
| Name: |
methyl-CpG binding domain protein 4; targeted mutation 2, Alfonso Bellacosa |
| MGI ID: |
MGI:2684310 |
| Synonyms: |
delta2-5 |
| Gene: |
Mbd4 Location: Chr6:115817658-115830332 bp, - strand Genetic Position: Chr6, 53.72 cM
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| Alliance: |
Mbd4tm2Abc page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:86981
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| Parent Cell Line: |
Other (see notes) (ES Cell)
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| Strain of Origin: |
129/Sv
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A genomic fragment encompassing exons 2, 3, 4, and 5 was replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region encoded portions of the 5-methylcytosine binding and catalytic domains. Transcript was undetected by RT-PCR analysis of homozygous MEFs.
(J:86981)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Mbd4 Mutation: |
32 strains or lines available
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ES cell line = R1 ((129X1/SvJ x 129S1/Sv)F1-Kitl+) or W9.5 (129S1/Sv-p+ Tyr+ Kitl+).
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| Original: |
J:86981 Cortellino S, et al., The base excision repair enzyme MED1 mediates DNA damage response to antitumor drugs and is associated with mismatch repair system integrity. Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15071-6 |
| All: |
5 reference(s) |
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Analysis Tools
