Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | Notes | References

Symbol:	Gt(ROSA)26Sortm1(Notch1)Dam
Name:	gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Douglas A Melton
MGI ID:	MGI:2684314
Synonyms:	Lox-stop-Lox-RosaNICD-ires-GFP, R26fN1-ICD, R26fsN1ICD, R26N1ICD, R26-NICD, R26NotchIC, R-NICD, Rosa26LSL-NICD, Rosa26N1ICD, Rosa26NIC, Rosa26NotchIC-IRES-GFP, Rosa26-StopFloxed-NICD, RosaICNLSL, RosaN1-IC, RosaNICD, ROSA-NICD, RosaNICD1, RosaNICDflox, RosaNotch, Rosa-NotchIC-IRES-GFP, TGNICDflox
Gene:	Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance:	Gt(ROSA)26Sortm1(Notch1)Dam page

Germline Transmission:	Earliest citation of germline transmission: J:86975
Parent Cell Line:	AK7 (ES Cell)
Strain of Origin:	129S4/SvJaeSor

Allele Type:    Targeted (Conditional ready, Inserted expressed sequence, Reporter) Mutation:    Insertion   Gt(ROSA)26Sortm1(Notch1)Dam expresses 1 gene Knock-in expresses: Organism Expressed Gene Note mouse Notch1 (MGI:97363)   Mutation details: A targeting vector containing a floxed neo cassette followed by a mouse Notch1 sequence fragment and GFP was inserted at the endogenous locus. Excision of the floxed neo cassette leads to the expression of the Notch1 sequence encoding an intracellular portion of NOTCH1 (amino acids 1749-2293), but lacking the c-terminal PEST domain. IRES preceded the sequence encoding the nuclear-localized enhanced GFP. (J:86975)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	16 anatomical structure(s)

List all tumor models in MMHCdb carrying Gt(ROSA)26Sortm1(Notch1)Dam

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:	994 strains or lines available

Original:	J:86975 Murtaugh LC, et al., Notch signaling controls multiple steps of pancreatic differentiation. Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):14920-5
All:	240 reference(s)