About   Help   FAQ
Casp3tm1Kin
Targeted Allele Detail
Summary
Symbol: Casp3tm1Kin
Name: caspase 3; targeted mutation 1, Ken-Ichi Nakayama
MGI ID: MGI:2684608
Synonyms: caspase-3 -
Gene: Casp3  Location: Chr8:47070326-47092724 bp, + strand  Genetic Position: Chr8, 26.39 cM
Alliance: Casp3tm1Kin page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:69809
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A neomycin selection cassette replaced a 9.8 kb genomic fragment containing sequences encoding the QACRG motif of the catalytic site of the encoded protien. RT-PCR and immunohistochemistry experiments confirmed that no detectable transcript and protein was made from this allele. (J:69809)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Casp3 Mutation:  33 strains or lines available
References
Original:  J:69809 Morishita H, et al., Deafness due to degeneration of cochlear neurons in caspase-3-deficient mice. Biochem Biophys Res Commun. 2001 Jun 1;284(1):142-9
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory