Summary | Mutation origin | Mutation description | Expression | Recombinase activity | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Emx1tm1(cre)Krj
Name:	empty spiracles homeobox 1; targeted mutation 1, Kevin R Jones
MGI ID:	MGI:2684610
Synonyms:	emx1-cre, Emx1-Cre, Emx1Cre, Emx1IREScre, Emx1-IRES-Cre
Gene:	Emx1  Location: Chr6:85164913-85181445 bp, + strand  Genetic Position: Chr6, 37.21 cM
Alliance:	Emx1tm1(cre)Krj page

Germline Transmission:	Earliest citation of germline transmission: J:78098
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Recombinase) Mutation:    Insertion   Emx1tm1(cre)Krj expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Emx1 (MGI:95387)   Mutation details: An IRES-cre gene followed by an FRT flanked PGK-neomycin gene was inserted 120 bp 3' of the stop codon. The neomycin gene was later removed in vivo by crossing to an Flp recombinase expressing transgenic strain. The protein product of this gene was produced in normal quantities as confirmed by Western blot analysis. Cre recombinase expression was characterized by crossing to a Rosa26 strain. (J:78098)

Activity:	Tissue activity of this recombinase allele
Driver:	Emx1 (mouse) Summary of all recombinase alleles driven by Emx1. Comparative matrix view of recombinase activities Alliance mouse Emx1 gene page

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

932 assay results 43 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Emx1 Mutation:	34 strains or lines available

Original:	J:78098 Gorski JA, et al., Cortical excitatory neurons and glia, but not GABAergic neurons, are produced in the Emx1-expressing lineage. J Neurosci. 2002 Aug 1;22(15):6309-14
All:	702 reference(s)