Psen1<tm1Vln> Targeted Allele Detail MGI Mouse (MGI:2684616)

Psen1^tm1Vln
Targeted Allele Detail

Summary

Symbol:	Psen1^tm1Vln
Name:	presenilin 1; targeted mutation 1, Fred Van Leuven
MGI ID:	MGI:2684616
Synonyms:	PS1-flox
Gene:	Psen1 Location: Chr12:83734926-83781869 bp, + strand Genetic Position: Chr12, 38.84 cM
Alliance:	Psen1^tm1Vln page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:87229
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:		Targeted (Conditional ready, No functional change)
Mutation:		Insertion
		Exon 7 was flanked by a single loxP site in intron 6 and floxed neo cassette in intron 7. (J:87229)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Mice Carrying this Mutation:

8 assay results

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available Cell Lines: 0 lines available
Carrying any Psen1 Mutation:	48 strains or lines available

References

Original:	J:87229 Dewachter I, et al., Neuronal deficiency of presenilin 1 inhibits amyloid plaque formation and corrects hippocampal long-term potentiation but not a cognitive defect of amyloid precursor protein [V717I] transgenic mice. J Neurosci. 2002 May 1;22(9):3445-53
All:	7 reference(s)

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