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Pik3c2b Gene Detail
Summary
  • Symbol
    Pik3c2b
  • Name
    phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
  • Synonyms
    C330011J12Rik, PI3K-C2beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685045
    NCBI Gene: 240752
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:132973410-133036429 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 57.75 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1755 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685045
 protein coding gene Chr1:132973405-133036429 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016479
 protein coding gene Chr1:136556770-136621008 (+)
A/J MGP_AJ_G0016462
 protein coding gene Chr1:131497078-131561764 (+)
AKR/J MGP_AKRJ_G0016427
 protein coding gene Chr1:135362059-135434427 (+)
BALB/cJ MGP_BALBcJ_G0016422
 protein coding gene Chr1:131831075-131894302 (+)
C3H/HeJ MGP_C3HHeJ_G0016248
 protein coding gene Chr1:135506609-135572504 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016883
 protein coding gene Chr1:141631253-141698855 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014594
 protein coding gene Chr1:124656260-124719417 (+)
CAST/EiJ MGP_CASTEiJ_G0015828
 protein coding gene Chr1:134529152-134597751 (+)
CBA/J MGP_CBAJ_G0016220
 protein coding gene Chr1:146451748-146524495 (+)
DBA/2J MGP_DBA2J_G0016327
 protein coding gene Chr1:130458199-130523551 (+)
FVB/NJ MGP_FVBNJ_G0016326
 protein coding gene Chr1:129107233-129170542 (+)
LP/J MGP_LPJ_G0016398
 protein coding gene Chr1:137876119-137939040 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016351
 protein coding gene Chr1:152233255-152298406 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016919
 protein coding gene Chr1:135120358-135184781 (+)
PWK/PhJ MGP_PWKPhJ_G0015614
 protein coding gene Chr1:129464235-129529850 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015401
 protein coding gene Chr1:134075443-134140212 (+)
WSB/EiJ MGP_WSBEiJ_G0015890
 protein coding gene Chr1:135122431-135188063 (+)



Homology
more
  • Human Ortholog
    PIK3C2B, phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PIK3C2B, phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
  • Synonyms
    C2-PI3K
  • Links
    NCBI Gene ID: 5287
    neXtProt AC: NX_O00750
    UniProt: O00750

  • Chr Location
    1q32.1; chr1:204422628-204494805 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    21 phenotype references
Mice homozygous for a knock-out allele exhibit normal epidermal growth, differentiation and function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    802
  • Tissues
    96
  • cDNA Data
    16
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 240752 NCBI Gene Model | MGI Sequence Detail 63020 C57BL/6J ±  kb
transcript NM_001099276 RefSeq | MGI Sequence Detail 7929 C57BL/6  
polypeptide NP_001092746 RefSeq | MGI Sequence Detail 1632 C57BL/6  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • InterPro Domains
    IPR016024 Armadillo-type fold
    IPR000008 C2 domain
    IPR035892 C2 domain superfamily
    IPR002420 C2 phosphatidylinositol 3-kinase-type domain
    IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
    IPR036940 Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily
    IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
    IPR000341 Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
    IPR042134 Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta, PX domain
    IPR015433 Phosphatidylinositol kinase
    IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
    IPR042236 Phosphoinositide 3-kinase, accessory (PIK) domain superfamily
    IPR001683 Phox homology
    IPR011009 Protein kinase-like domain superfamily
    IPR036871 PX domain superfamily
    IPR029071 Ubiquitin-like domain superfamily
Molecular
Reagents
less
  • All nucleic 16
    cDNA 16

    Microarray probesets 1
References
more
  • Summaries
    All 46
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 21
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:341022 Massana-Munoz X, et al., Inactivating the lipid kinase activity of PI3KC2beta is sufficient to rescue myotubular myopathy in mice. JCI Insight. 2023 May 8;8(9)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory