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Megf10 Gene Detail
Summary
  • Symbol
    Megf10
  • Name
    multiple EGF-like-domains 10
  • Synonyms
    3000002B06Rik, LOC240312
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685177
    NCBI Gene: 70417
  • Alliance
    gene page
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:57266162-57430539 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 31.50 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4591 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685177
 protein coding gene Chr18:57266162-57430539 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024447
 protein coding gene Chr18:56552235-56717660 (+)
A/J MGP_AJ_G0024413
 protein coding gene Chr18:54311007-54471188 (+)
AKR/J MGP_AKRJ_G0024383
 protein coding gene Chr18:55803125-55968073 (+)
BALB/cJ MGP_BALBcJ_G0024413
 protein coding gene Chr18:54485593-54645497 (+)
C3H/HeJ MGP_C3HHeJ_G0024180
 protein coding gene Chr18:56010306-56173631 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024859
 protein coding gene Chr18:58334438-58517535 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022291
 protein coding gene Chr18:53913554-54071563 (+)
CAST/EiJ MGP_CASTEiJ_G0023654
 protein coding gene Chr18:56042233-56206986 (+)
CBA/J MGP_CBAJ_G0024150
 protein coding gene Chr18:60177858-60373336 (+)
DBA/2J MGP_DBA2J_G0024280
 protein coding gene Chr18:54003213-54172085 (+)
FVB/NJ MGP_FVBNJ_G0024247
 protein coding gene Chr18:53397427-53559616 (+)
LP/J MGP_LPJ_G0024365
 protein coding gene Chr18:56507214-56682444 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024277
 protein coding gene Chr18:61818683-61990673 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024906
 protein coding gene Chr18:55918189-56081438 (+)
PWK/PhJ MGP_PWKPhJ_G0023398
 protein coding gene Chr18:54028725-54188898 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023204
 protein coding gene Chr18:56007306-56160910 (+)
WSB/EiJ MGP_WSBEiJ_G0023717
 protein coding gene Chr18:55842142-56006336 (+)



Homology
more
  • Human Ortholog
    MEGF10, multiple EGF like domains 10
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MEGF10, multiple EGF like domains 10
  • Synonyms
    CMYO10A, CMYO10B, CMYP10A, CMYP10B, EMARDD, SR-F3
  • Links
    NCBI Gene ID: 84466
    neXtProt AC: NX_Q96KG7
    UniProt: Q96KG7

  • Chr Location
    5q23.2; chr5:127229300-127465737 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human MEGF10 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted allele exhibit abnormal spacing of starburst amacrine cells and horizontal cells. Homozygotes for another targeted allele exhibit impaired phagocytosis of apoptotic cells by astrocytes. Mice heterozygous for this same allele exhibit mild disorganization of starburts amacrine cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    771
  • Tissues
    35
  • cDNA Data
    24
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 70417 NCBI Gene Model | MGI Sequence Detail 164378 C57BL/6J ±  kb
    transcript NM_001001979 RefSeq | MGI Sequence Detail 7514 C57BL/6  
    polypeptide Q6DIB5 UniProt | EBI | MGI Sequence Detail 1147 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 30
      cDNA 24
      Primer pair 4
      Other 2

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1917667
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 9
      Gene Ontology 11
      Phenotypes 17
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:353797 Kozlowski C, et al., Retinal neurons establish mosaic patterning by excluding homotypic somata from their dendritic territories. Cell Rep. 2024 Aug 27;43(8):114615
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory