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Ccn6 Gene Detail
Summary
  • Symbol
    Ccn6
  • Name
    cellular communication network factor 6
  • Synonyms
    CCN6, LOC327743, Wisp3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685581
    NCBI Gene: 327743
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr10:39026966-39039790 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 20.19 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    562 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685581
 protein coding gene Chr10:39026966-39049484 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017150
 protein coding gene Chr10:37641775-37655676 (-)
A/J MGP_AJ_G0017127
 protein coding gene Chr10:36648029-36660776 (-)
AKR/J MGP_AKRJ_G0017087
 protein coding gene Chr10:37150348-37163113 (-)
BALB/cJ MGP_BALBcJ_G0017090
 protein coding gene Chr10:36674606-36687374 (-)
C3H/HeJ MGP_C3HHeJ_G0016910
 protein coding gene Chr10:37471487-37484871 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017548
 protein coding gene Chr10:38806598-38820269 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015245
 protein coding gene Chr10:34638952-34651449 (-)
CAST/EiJ MGP_CASTEiJ_G0016489
 protein coding gene Chr10:37616400-37630820 (-)
CBA/J MGP_CBAJ_G0016884
 protein coding gene Chr10:40604228-40618112 (-)
DBA/2J MGP_DBA2J_G0016989
 protein coding gene Chr10:36169692-36182801 (-)
FVB/NJ MGP_FVBNJ_G0016984
 protein coding gene Chr10:35671285-35684069 (-)
LP/J MGP_LPJ_G0017066
 protein coding gene Chr10:37612672-37625449 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017014
 protein coding gene Chr10:41483670-41497647 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017584
 protein coding gene Chr10:37137754-37151058 (-)
PWK/PhJ MGP_PWKPhJ_G0016270
 protein coding gene Chr10:35991964-36005943 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016054
 protein coding gene Chr10:36912567-36929312 (-)
WSB/EiJ MGP_WSBEiJ_G0016552
 protein coding gene Chr10:37412094-37424823 (-)



Homology
more
  • Human Ortholog
    CCN6, cellular communication network factor 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CCN6, cellular communication network factor 6
  • Synonyms
    LIBC, PPAC, PPD, PPRD, WISP-3, WISP3
  • Links
    NCBI Gene ID: 8838
    neXtProt AC: NX_O95389
    UniProt: O95389

  • Chr Location
    6q21; chr6:112052813-112069686 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Ccn6 mouse models; 2 with human CCN6 associations

Human Disease Mouse Models
      
IDs
 View 3 models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 3 alleles in 4 genetic backgrounds
    16 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice are viable and fertile with no obvious abnormalities in size, weight, skeletal development, ossification, or the occurrence of joint disease.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    714
  • Tissues
    6
  • cDNA Data
    1
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000062074 Ensembl Gene Model | MGI Sequence Detail 12825 C57BL/6J ±  kb
    transcript ENSMUST00000076713 Ensembl | MGI Sequence Detail 1419 Not Applicable  
    polypeptide ENSMUSP00000076003 Ensembl | MGI Sequence Detail 354 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000017428 cellular communication network factor 6
      (term hierarchy)
    • InterPro Domains
      IPR043973 CCN, TSP1 domain
      IPR050941 Cellular Communication Network Factor
      IPR006207 Cystine knot, C-terminal
      IPR006208 Glycoprotein hormone subunit beta
      IPR009030 Growth factor receptor cysteine-rich domain superfamily
      IPR012395 IGFBP-related, CNN
      IPR000867 Insulin-like growth factor-binding protein, IGFBP
      IPR017891 Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
      IPR000884 Thrombospondin type-1 (TSP1) repeat
      IPR036383 Thrombospondin type-1 (TSP1) repeat superfamily
    • GlyGen
      D3Z5L9 1 site
    Molecular
    Reagents
    less
    • All nucleic 3
      cDNA 1
      Primer pair 2

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:3641683, MGI:6209573
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 3
      Diseases 3
      Gene Ontology 6
      Phenotypes 13
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:321647 Lester WC, et al., Aurora A Kinase (AURKA) is required for male germline maintenance and regulates sperm motility in the mouse. Biol Reprod. 2021 Dec 20;105(6):1603-1616
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory