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Prdm12 Gene Detail
Summary
  • Symbol
    Prdm12
  • Name
    PR domain containing 12
  • Synonyms
    LOC381359
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685844
    NCBI Gene: 381359
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:31530049-31545807 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 21.85 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    377 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685844
 protein coding gene Chr2:31526767-31545807 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025587
 protein coding gene Chr2:29997288-30013024 (+)
A/J MGP_AJ_G0025565
 protein coding gene Chr2:28758168-28773894 (+)
AKR/J MGP_AKRJ_G0025534
 protein coding gene Chr2:29729059-29744793 (+)
BALB/cJ MGP_BALBcJ_G0025561
 protein coding gene Chr2:28888142-28903890 (+)
C3H/HeJ MGP_C3HHeJ_G0025322
 protein coding gene Chr2:29664440-29680178 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026006
 protein coding gene Chr2:30935346-30951109 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023414
 protein coding gene Chr2:27514800-27530349 (+)
CAST/EiJ MGP_CASTEiJ_G0024784
 protein coding gene Chr2:29607938-29623694 (+)
CBA/J MGP_CBAJ_G0025299
 protein coding gene Chr2:32043242-32058982 (+)
DBA/2J MGP_DBA2J_G0025432
 protein coding gene Chr2:28532398-28548144 (+)
FVB/NJ MGP_FVBNJ_G0025395
 protein coding gene Chr2:28390699-28406437 (+)
LP/J MGP_LPJ_G0025518
 protein coding gene Chr2:29888439-29904171 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025425
 protein coding gene Chr2:31798307-31814033 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026064
 protein coding gene Chr2:29661786-29677505 (+)
PWK/PhJ MGP_PWKPhJ_G0024531
 protein coding gene Chr2:28428703-28444732 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024331
 protein coding gene Chr2:29807500-29823104 (+)
WSB/EiJ MGP_WSBEiJ_G0024852
 protein coding gene Chr2:29832403-29848162 (+)



Homology
more
  • Human Ortholog
    PRDM12, PR/SET domain 12
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRDM12, PR/SET domain 12
  • Synonyms
    HSAN8, PFM9
  • Links
    NCBI Gene ID: 59335
    neXtProt AC: NX_Q9H4Q4
    UniProt: Q9H4Q4

  • Chr Location
    9q34.12; chr9:130664594-130682986 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PRDM12 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 3 alleles in 3 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit neonatal lethality, apoptosis of nociception neurons, and small trigemminal, superior jugular, and dorsal root ganglia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    948
  • Tissues
    157
  • cDNA Data
    3
  • Literature Summary
    19
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000079466 Ensembl Gene Model | MGI Sequence Detail 15759 C57BL/6J ±  kb
    transcript ENSMUST00000113470 Ensembl | MGI Sequence Detail 2471 Not Applicable  
    polypeptide ENSMUSP00000109098 Ensembl | MGI Sequence Detail 365 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 3
      Primer pair 4
      Other 1
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 19
      Gene Ontology 7
      Phenotypes 17
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory