About   Help   FAQ
Aim2 Gene Detail
Summary
  • Symbol
    Aim2
  • Name
    absent in melanoma 2
  • Synonyms
    Ifi210, LOC383619
  • Feature Type
    protein coding gene
  • IDs
    MGI:2686159
    NCBI Gene: 383619
  • Alliance
    gene page
  • Transcription Start Sites
    18 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:173178445-173293606 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 80.33 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2810 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2686159
 protein coding gene Chr1:173177105-173293606 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016809
 protein coding gene Chr1:179281358-179395907 (+)
A/J MGP_AJ_G0016786
 protein coding gene Chr1:171932250-172046877 (+)
AKR/J MGP_AKRJ_G0016752
 protein coding gene Chr1:177157548-177300165 (+)
BALB/cJ MGP_BALBcJ_G0016746
 protein coding gene Chr1:172474547-172616610 (+)
C3H/HeJ MGP_C3HHeJ_G0016571
 protein coding gene Chr1:177761005-177808688 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017209
 protein coding gene Chr1:185258101-185386443 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014915
 protein coding gene Chr1:163559434-163911161 (+)
CAST/EiJ MGP_CASTEiJ_G0016151
 protein coding gene Chr1:177082627-177204880 (+)
CBA/J MGP_CBAJ_G0016545
 protein coding gene Chr1:191865919-191987119 (+)
DBA/2J MGP_DBA2J_G0016652
 protein coding gene Chr1:170893053-171029828 (+)
FVB/NJ MGP_FVBNJ_G0016649
 protein coding gene Chr1:169105366-169223225 (+)
LP/J MGP_LPJ_G0016723
 protein coding gene Chr1:180355254-180477955 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016675
 protein coding gene Chr1:199079568-199199890 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017245
 protein coding gene Chr1:177049935-177175462 (+)
PWK/PhJ MGP_PWKPhJ_G0015938
 protein coding gene Chr1:170254566-170370772 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015720
 protein coding gene Chr1:175983643-176104394 (+)
WSB/EiJ MGP_WSBEiJ_G0016215
 protein coding gene Chr1:177147558-177263824 (+)



Homology
more
  • Human Ortholog
    AIM2, absent in melanoma 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AIM2, absent in melanoma 2
  • Synonyms
    PYHIN4
  • Links
    NCBI Gene ID: 9447
    neXtProt AC: NX_O14862
    UniProt: O14862

  • Chr Location
    1q23.1-q23.2; chr1:159055051-159187843 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 4 alleles in 6 genetic backgrounds
    7 phenotypes from multigenic genotypes
    130 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit increased susceptibility to bacterial and viral infections with altered cytokine production and inflammatory cell death (pyrotosis).
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    67
  • GO References
    23
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037860 Ensembl Gene Model | MGI Sequence Detail 115162 C57BL/6J ±  kb
    transcript ENSMUST00000166137 Ensembl | MGI Sequence Detail 2079 Not Applicable  
    polypeptide ENSMUSP00000132253 Ensembl | MGI Sequence Detail 354 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 10

      Microarray probesets 1
    References
    more
    • Summaries
      All 177
      Gene Ontology 23
      Phenotypes 130
    • Earliest
      J:85162 Hansen J, et al., A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22
    • Latest
      J:354143 Moran EA, et al., IFI207, a young and fast-evolving protein, controls retroviral replication via the STING pathway. mBio. 2024 Jul 17;15(7):e0120924
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory