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Meioc Gene Detail
Summary
  • Symbol
    Meioc
  • Name
    meiosis specific with coiled-coil domain
  • Synonyms
    Gm1564, LOC268491, LOC380729
  • Feature Type
    protein coding gene
  • IDs
    MGI:2686410
    NCBI Gene: 268491
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:102556177-102573066 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 66.48 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    298 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2686410
 protein coding gene Chr11:102554542-102573066 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019241
 protein coding gene Chr11:105668970-105689616 (+)
A/J MGP_AJ_G0019209
 protein coding gene Chr11:101198121-101216710 (+)
AKR/J MGP_AKRJ_G0019178
 protein coding gene Chr11:104334975-104353496 (+)
BALB/cJ MGP_BALBcJ_G0019183
 protein coding gene Chr11:101680754-101699550 (+)
C3H/HeJ MGP_C3HHeJ_G0018992
 protein coding gene Chr11:104536824-104555285 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019632
 protein coding gene Chr11:108954695-108975225 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017258
 protein coding gene Chr11:98626669-98648484 (+)
CAST/EiJ MGP_CASTEiJ_G0018546
 protein coding gene Chr11:105540465-105560481 (+)
CBA/J MGP_CBAJ_G0018961
 protein coding gene Chr11:113449554-113472097 (+)
DBA/2J MGP_DBA2J_G0019073
 protein coding gene Chr11:100713577-100731991 (+)
FVB/NJ MGP_FVBNJ_G0019063
 protein coding gene Chr11:100255899-100274284 (+)
LP/J MGP_LPJ_G0019142
 protein coding gene Chr11:106193025-106213046 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019094
 protein coding gene Chr11:112930885-112948833 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019670
 protein coding gene Chr11:104694249-104723232 (+)
PWK/PhJ MGP_PWKPhJ_G0018309
 protein coding gene Chr11:101782042-101811491 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018101
 protein coding gene Chr11:104458429-104476841 (+)
WSB/EiJ MGP_WSBEiJ_G0018595
 protein coding gene Chr11:104695634-104717283 (+)



Homology
more
  • Human Ortholog
    MEIOC, meiosis specific with coiled-coil domain
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MEIOC, meiosis specific with coiled-coil domain
  • Synonyms
    C17orf104
  • Links
    NCBI Gene ID: 284071
    neXtProt AC: NX_A2RUB1
    UniProt: A2RUB1

  • Chr Location
    17q21.31; chr17:44656404-44690308 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit infertility with small gonads, absent germ cells and arrested meiosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    817
  • Tissues
    42
  • cDNA Data
    12
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 268491 NCBI Gene Model | MGI Sequence Detail 16890 C57BL/6J ±  kb
    transcript NM_001127576 RefSeq | MGI Sequence Detail 4577 C57BL/6  
    polypeptide A2AG06 UniProt | EBI | MGI Sequence Detail 965 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000059681 meiosis-specific coiled-coil domain-containing protein MEIOC
      (term hierarchy)
    • InterPro Domains
      IPR027963 Meiosis-specific coiled-coil domain-containing protein MEIOC
    Molecular
    Reagents
    less
    • All nucleic 17
      Genomic 2
      cDNA 12
      Primer pair 3

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2685509
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 6
      Gene Ontology 5
      Phenotypes 12
    • Earliest
      J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
    • Latest
      J:352963 Pfaltzgraff NG, et al., Destabilization of mRNAs enhances competence to initiate meiosis in mouse spermatogenic cells. Development. 2024 Jul 15;151(14)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory