Fgf8<tm3Mrc> Targeted Allele Detail MGI Mouse (MGI:2686826)

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Fgf8^tm3Mrc
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Fgf8^tm3Mrc
Name:	fibroblast growth factor 8; targeted mutation 3, Mario R Capecchi
MGI ID:	MGI:2686826
Synonyms:	Fgf8^APN, Fgf8^CR, Fgf8^H, Fgf8^hy
Gene:	Fgf8 Location: Chr19:45725237-45731354 bp, - strand Genetic Position: Chr19, 38.75 cM, cytoband C3-D
Alliance:	Fgf8^tm3Mrc page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:66265
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Mutation
description

Allele Type:		Targeted (Conditional ready, Hypomorph, Reporter)
Mutation:		Insertion
		Mutation details: This hypomorphic allele was generated by inserting an frt-flanked neomycin cassette into intron 5. Single loxP sites located in introns 4 and 5, flank exon 5 and the neomycin cassette. An alkaline phosphatase gene was inserted just 5' to the second lox P site such that upon cre-mediated recombination, the alkaline phosphatase gene is expressed under the control of the Fgf8 gene. Fgf8^tm1Mrc and Fgf8^tm2Mrc were respectively generated by cre- and flp-mediated recombination of this allele. (J:66265, J:87304)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	15 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Fgf8 Mutation:	21 strains or lines available

References

Original:	J:66265 Moon AM, et al., Fgf8 is required for outgrowth and patterning of the limbs. Nat Genet. 2000 Dec;26(4):455-9
All:	8 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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