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Hoxa3tm1(cre)Moon
Targeted Allele Detail
Summary
Symbol: Hoxa3tm1(cre)Moon
Name: homeobox A3; targeted mutation 1, Anne M Moon
MGI ID: MGI:2686838
Synonyms: A3cre, Hoxa3Cre, Hoxa3-Ires-Cre
Gene: Hoxa3  Location: Chr6:52146042-52190316 bp, - strand  Genetic Position: Chr6, 25.4 cM
Alliance: Hoxa3tm1(cre)Moon page
Abnormal caudal body formation in Bmp4tm4Blh/Bmp4+ Bmp7tm1.1Dgra/Bmp7tm1.1Dgra Hoxa3tm1(cre)Moon/Hoxa3+ embryos

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:87304
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Hoxa3tm1(cre)Moon expression driven by 1 gene
 
Mutation details: An IRES-cre cassette followed by an frt-flanked neomycin gene was targeted downstream of the Hoxa3 coding region. The cassette was inserted 4 bp 3' of the stop codon and upstream of the polyadenylation signal. (J:87304)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Hoxa3 (mouse)
Summary of all recombinase alleles driven by Hoxa3.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 60 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hoxa3 Mutation:  24 strains or lines available
References
Original:  J:87304 Macatee TL, et al., Ablation of specific expression domains reveals discrete functions of ectoderm- and endoderm-derived FGF8 during cardiovascular and pharyngeal development. Development. 2003 Dec;130(25):6361-74
All:  17 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory