Mpltm1Fjs
Targeted Allele Detail
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| Symbol: |
Mpltm1Fjs |
| Name: |
myeloproliferative leukemia virus oncogene; targeted mutation 1, Frederic J de Sauvage |
| MGI ID: |
MGI:2686901 |
| Synonyms: |
c-Mpl-, c-Mpl delta60 |
| Gene: |
Mpl Location: Chr4:118299612-118314710 bp, - strand Genetic Position: Chr4, 54.61 cM, cytoband D
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| Alliance: |
Mpltm1Fjs page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:87416
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| Parent Cell Line: |
GS1 (ES Cell)
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| Strain of Origin: |
129/Sv
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Exons 11 and 12, which includes the sequence for the intracellular region, were replaced with a complex sequence including a cDNA fragment encoding only the first half of the cytoplasmic signaling domain, an SV40 polyadenylation site, and a floxed PGK-neomycin cassette. Western blot analysis demonstrated that the resulting protein product had been modified to a size consistent with a 60 amino acid deletion.
(J:87416)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Mpl Mutation: |
48 strains or lines available
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| Original: |
J:87416 Luoh SM, et al., Role of the distal half of the c-Mpl intracellular domain in control of platelet production by thrombopoietin in vivo. Mol Cell Biol. 2000 Jan;20(2):507-15 |
| All: |
12 reference(s) |
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Analysis Tools
