Hcn1<tm2Kndl> Targeted Allele Detail MGI Mouse (MGI:2686951)

Hcn1^tm2Kndl
Targeted Allele Detail

Summary

Symbol:	Hcn1^tm2Kndl
Name:	hyperpolarization activated cyclic nucleotide gated potassium channel 1; targeted mutation 2, Eric R Kandel
MGI ID:	MGI:2686951
Synonyms:	Hcn1-, HCN1 knockout
Gene:	Hcn1 Location: Chr13:117738856-118117564 bp, + strand Genetic Position: Chr13, 66.34 cM
Alliance:	Hcn1^tm2Kndl page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:86763
Parent Cell Line:	MM13 (ES Cell)
Strain of Origin:	129S/SvEv

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A loxP site was inserted upstream of the pore-S6 domain containing exon. At the same time, a floxed neomycin cassette was introduced downstream. Cells in which transient Cre recombinase expression of properly targeted ES cells resulted in excision of both the neomycin gene and the pore-S6 exon were selected. Both mRNA and protein were shown to be absent in the brains of mice homozygous for this allele. (J:86763)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 4 strains available Cell Lines: 0 lines available
Carrying any Hcn1 Mutation:	49 strains or lines available

References

Original:	J:86763 Nolan MF, et al., The hyperpolarization-activated HCN1 channel is important for motor learning and neuronal integration by cerebellar Purkinje cells. Cell. 2003 Nov 26;115(5):551-64
All:	39 reference(s)

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