Ar<tm1.1Chc> Targeted Allele Detail MGI Mouse (MGI:2687199)

Ar^tm1.1Chc
Targeted Allele Detail

Summary

Symbol:	Ar^tm1.1Chc
Name:	androgen receptor; targeted mutation 1.1, Chawnshang Chang
MGI ID:	MGI:2687199
Synonyms:	AR^-, ARKO, GARKO
Gene:	Ar Location: ChrX:97192375-97366821 bp, + strand Genetic Position: ChrX, 42.82 cM
Alliance:	Ar^tm1.1Chc page

Immunostaining of androgen receptor and histological analysis of testes of Ar^tm1.1Chc/Y mice

Show the 3 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:81789
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S/SvEv

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: The loxP flanked region including exon 2 was excised from Ar^tm1Chc via cre mediated recombination. Exon 2 encodes the second zinc finger of the DNA-binding domain. (J:81789)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Ar Mutation:	23 strains or lines available

References

Original:	J:81789 Yeh S, et al., Generation and characterization of androgen receptor knockout (ARKO) mice: an in vivo model for the study of androgen functions in selective tissues. Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13498-503
All:	19 reference(s)

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