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P2rx2tm1Ckn
Targeted Allele Detail
Summary
Symbol: P2rx2tm1Ckn
Name: purinergic receptor P2X, ligand-gated ion channel, 2; targeted mutation 1, Debra A Cockayne
MGI ID: MGI:2687349
Synonyms: P2X2-
Gene: P2rx2  Location: Chr5:110487678-110491078 bp, - strand  Genetic Position: Chr5, 53.49 cM
Alliance: P2rx2tm1Ckn page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:88199
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: Exons 2 through 11 were deleted and replaced by a neomycin resistance cassette by homologous recombination in ES cells. RT-PCR analysis confirmed absence of mRNA in whole brain and testis from homozygous mutant mice, whereas the expected band was obtained in wild-type mice. (J:88199)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any P2rx2 Mutation:  31 strains or lines available
References
Original:  J:88199 Khakh BS, et al., ATP modulation of excitatory synapses onto interneurons. J Neurosci. 2003 Aug 13;23(19):7426-37
All:  22 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory