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Ednratm2Ywa
Targeted Allele Detail
Summary
Symbol: Ednratm2Ywa
Name: endothelin receptor type A; targeted mutation 2, Masashi Yanagisawa
MGI ID: MGI:2687362
Synonyms: Ednrafl, ETAflox
Gene: Ednra  Location: Chr8:78389658-78451081 bp, - strand  Genetic Position: Chr8, 36.63 cM, cytoband C2
Alliance: Ednratm2Ywa page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:86476
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation details: A genomic region encompassing exons 6, 7, and 8 were flanked by an upstream single loxP site and a downstream floxed neo cassette. (J:86476)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 12 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ednra Mutation:  35 strains or lines available
References
Original:  J:86476 Kedzierski RM, et al., Cardiomyocyte-specific endothelin A receptor knockout mice have normal cardiac function and an unaltered hypertrophic response to angiotensin II and isoproterenol. Mol Cell Biol. 2003 Nov;23(22):8226-32
All:  19 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory