Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	TxnipHyplip1
Name:	thioredoxin interacting protein; hyperlipidemia 1
MGI ID:	MGI:2687368
Synonyms:	Txnip-, txniphcb
Gene:	Txnip  Location: Chr3:96465273-96469173 bp, + strand  Genetic Position: Chr3, 41.93 cM, cytoband F2.2
Alliance:	TxnipHyplip1 page

Strain of Origin:

HcB19/Dem

Allele Type:    Spontaneous (Hypomorph) Mutation:    Single point mutation   Mutation details: A T-to-A transversion mutation at coding nucleotide 291 in the 1,456-bp cDNA results in a tyrosine (TAT) to a stop codon (TAA) alteration at amino acid 97 (p.Y97*) in the encoded protein. This mutation was absent in the C3H parental strain and all other strains observed. A decreased level of mutant transcript was expressed from this allele. (J:75395) Inheritance:    Dominant

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

List all tumor models in MMHCdb carrying TxnipHyplip1

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Txnip Mutation:	49 strains or lines available

Original:	J:47109 Castellani LW, et al., Mapping a gene for combined hyperlipidaemia in a mutant mouse strain. Nat Genet. 1998 Apr;18(4):374-7
All:	13 reference(s)