Efnb3tm1Henk
Targeted Allele Detail
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| Symbol: |
Efnb3tm1Henk |
| Name: |
ephrin B3; targeted mutation 1, Mark Henkemeyer |
| MGI ID: |
MGI:3026700 |
| Synonyms: |
ephrinB3KO, ephrin-B3neo |
| Gene: |
Efnb3 Location: Chr11:69444918-69451031 bp, - strand Genetic Position: Chr11, 42.8 cM
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| Alliance: |
Efnb3tm1Henk page
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: An frt-flanked neo cassette and a loxP-flanked lacZ cassette were inserted at the endogenous locus. The neo cassette was inserted at a restriction site within intron 4 while the lacZ cassette was inserted in frame in exon 5, disrupting codons 264 through 340 which make up the majority of the cytoplasmic domain. Normal protein was undetected in homozygous mutant mice by Northern blot analysis, however a truncated transcript was detected. This mutation is expected to ablate both forward and reverse signaling. The presence of the neo cassette prevented expression of lacZ.
(J:87497)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Efnb3 Mutation: |
11 strains or lines available
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| Original: |
J:87497 Yokoyama N, et al., Forward signaling mediated by ephrin-B3 prevents contralateral corticospinal axons from recrossing the spinal cord midline. Neuron. 2001 Jan;29(1):85-97 |
| All: |
16 reference(s) |
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Analysis Tools
