Mre11a<tm1Jpt> Targeted Allele Detail MGI Mouse (MGI:3027036)

Mre11a^tm1Jpt
Targeted Allele Detail

Summary

Symbol:	Mre11a^tm1Jpt
Name:	MRE11A homolog A, double strand break repair nuclease; targeted mutation 1, John H J Petrini
MGI ID:	MGI:3027036
Synonyms:	Mre11^ATLD1
Gene:	Mre11a Location: Chr9:14695971-14748421 bp, + strand Genetic Position: Chr9, 4.33 cM
Alliance:	Mre11a^tm1Jpt page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:87088
Parent Cell Line:	AB2.2 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1^b-m2

Mutation
description

Allele Type:		Targeted (Humanized sequence)
Mutation:		Single point mutation
		Mutation details: An A-to-T transversion point mutation was engineered at nucleotide 1894 of the coding sequence to recapitulate a nonsense mutation identified in human patients (codon 633). This mutation results in the truncation of 75 amino acids. (J:87088)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

Tumor Data

List all tumor models in MMHCdb carrying Mre11a^tm1Jpt

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Mre11a Mutation:	49 strains or lines available

References

Original:	J:87088 Theunissen JW, et al., Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) mice. Mol Cell. 2003 Dec;12(6):1511-23
All:	14 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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