Tg(mI56i-cre)6-1Clou
Transgene Detail
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| Symbol: |
Tg(mI56i-cre)6-1Clou |
| Name: |
transgene insertion 6-1, David E Clouthier |
| MGI ID: |
MGI:3027060 |
| Synonyms: |
Dlx5/6-Cre |
| Transgene: |
Tg(mI56i-cre)6-1Clou Location: unknown
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| Alliance: |
Tg(mI56i-cre)6-1Clou page
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| Transgene Type: |
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Transgenic (Recombinase) |
| Mutation: |
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Insertion
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Tg(mI56i-cre)6-1Clou expression driven by
1 gene
Transgene expression driven by:
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Mutation details: The intergenic distal-less homeobox 5/6 enhancer (mI56i) is a 440 bp fragment, endogenously located between Dlx5 and Dlx6. In this transgenic construct, mouse mI56i was included immediately downstream of cDNA encoding a nuclear localization signal and cre. Additionally, a minimal beta-globin promoter was included in the construct. Expression of cre recombinase was first realized at E9.5 and observed in the apical ectodermal ridge, brain, and neural crest-derived mesenchyme of pharyngeal. Additional indications of expression were identified along the smooth muscle of the outflow tract of the heart, however, this pattern was not observed in the 6-2 line.
(J:87355)
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Activity: |
 Tissue activity of this recombinase allele
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Driver:
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mI56i
(mouse)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Founder lines 6-1 and 6-2 were generated. In general, the expression from line 6-1 was stronger than that of line 6-2 in all areas other than the brain.
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| Original: |
J:87355 Ruest LB, et al., Dlx5/6-enhancer directed expression of Cre recombinase in the pharyngeal arches and brain. Genesis. 2003 Dec;37(4):188-94 |
| All: |
2 reference(s) |
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Analysis Tools
