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Tg(mI56i-cre)6-2Clou
Transgene Detail
Summary
Symbol: Tg(mI56i-cre)6-2Clou
Name: transgene insertion 6-2, David E Clouthier
MGI ID: MGI:3027086
Synonyms: Dlx5/6-Cre
Transgene: Tg(mI56i-cre)6-2Clou  Location: unknown  
Alliance: Tg(mI56i-cre)6-2Clou page
Transgene
origin
Strain of Origin:  (C57BL/6J x SJL)F2
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Tg(mI56i-cre)6-2Clou expression driven by 1 gene
 
Mutation details: The intergenic distal-less homeobox 5/6 enhancer (mI56i) is a 440 bp fragment, endogenously located between Dlx5 and Dlx6. In this transgenic construct, mI56i was included immediately downstream of cDNA encoding a nuclear localization signal and cre. Additionally, a minimal beta-globin promoter was included in the construct. Expression of cre recombinase was first realized at E9.5 and observed in the apical ectodermal ridge, brain, and neural crest-derived mesenchyme of pharyngeal. (J:87355)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: mI56i (mouse)
Summary of all recombinase alleles driven by mI56i.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Notes
Founder lines 6-1 and 6-2 were generated. In general, the expression from line 6-1 was stronger than that of line 6-2 in all areas other than the brain.
References
Original:  J:87355 Ruest LB, et al., Dlx5/6-enhancer directed expression of Cre recombinase in the pharyngeal arches and brain. Genesis. 2003 Dec;37(4):188-94
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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11/12/2024
MGI 6.24 		The Jackson Laboratory