Itgamtm1Rws
Targeted Allele Detail
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| Symbol: |
Itgamtm1Rws |
| Name: |
integrin alpha M; targeted mutation 1, Richard W Stokes |
| MGI ID: |
MGI:3027319 |
| Synonyms: |
CD11b- |
| Gene: |
Itgam Location: Chr7:127661812-127717663 bp, + strand Genetic Position: Chr7, 69.93 cM, cytoband F4
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| Alliance: |
Itgamtm1Rws page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:65847
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| Parent Cell Line: |
HM-1 (ES Cell)
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| Strain of Origin: |
129P2/OlaHsd-Hprt1b-m3
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: 3' and 5' portions of exons 13 and 14, respectively, were replaced with a neomycin selection cassette inserted by homologous recombination. The insertion was expected to preclude the translation of the C-terminal, which includes the majority of the metal-binding domain and the transmembrane domain.
(J:65847)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Itgam Mutation: |
48 strains or lines available
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| Original: |
J:65847 Melo MD, et al., Utilization of CD11b knockout mice to characterize the role of complement receptor 3 (CR3, CD11b/CD18) in the growth of mycobacterium tuberculosis in macrophages. Cell Immunol. 2000 Oct 10;205(1):13-23 |
| All: |
3 reference(s) |
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Analysis Tools
