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Prg2tm1Nal
Targeted Allele Detail
Summary
Symbol: Prg2tm1Nal
Name: proteoglycan 2, bone marrow; targeted mutation 1, Nancy A Lee
MGI ID: MGI:3027719
Synonyms: MBP-, mMBP-1-
Gene: Prg2  Location: Chr2:84810805-84813976 bp, + strand  Genetic Position: Chr2, 49.45 cM
Alliance: Prg2tm1Nal page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:65655
Parent Cell Line:  GK129 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: Exons 2, 3, and 4 were replaced with a PGK-neomycin cassette. The replaced sequence includes sequences encoding the signal sequence, propolypeptide, and N-terminal 54 amino acids. RT-PCR demonstrated the absence of transcript. (J:65655)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Prg2 Mutation:  22 strains or lines available
References
Original:  J:65655 Denzler KL, et al., Eosinophil major basic protein-1 does not contribute to allergen-induced airway pathologies in mouse models of asthma. J Immunol. 2000 Nov 15;165(10):5509-17
All:  13 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory