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Spo11tm1Rdco
Targeted Allele Detail
Summary
Symbol: Spo11tm1Rdco
Name: SPO11 initiator of meiotic double stranded breaks; targeted mutation 1, R Daniel Camerini-Otero
MGI ID: MGI:3027823
Synonyms: Spo11-
Gene: Spo11  Location: Chr2:172819493-172835369 bp, + strand  Genetic Position: Chr2, 95.64 cM, cytoband H4
Alliance: Spo11tm1Rdco page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:65881
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: Exon 1 starting after the sequence coding for the 3rd amino acid after the second "in frame" ATG through nucleotide 35 of the first intron was replaced with a PGK-neomycin cassette in reverse orientation. This removes the splice donor site. Absence of transcript was confirmed by Northern blot analysis. (J:65881)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 8 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Spo11 Mutation:  21 strains or lines available
References
Original:  J:65881 Romanienko PJ, et al., The mouse spo11 gene is required for meiotic chromosome synapsis. Mol Cell. 2000 Nov;6(5):975-87
All:  17 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory