About   Help   FAQ
Spo11tm1Rdco
Targeted Allele Detail
Summary
Symbol: Spo11tm1Rdco
Name: SPO11 initiator of meiotic double stranded breaks; targeted mutation 1, R Daniel Camerini-Otero
MGI ID: MGI:3027823
Synonyms: Spo11-
Gene: Spo11  Location: Chr2:172819493-172835369 bp, + strand  Genetic Position: Chr2, 95.64 cM, cytoband H4
Alliance: Spo11tm1Rdco page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:65881
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: Exon 1 starting after the sequence coding for the 3rd amino acid after the second "in frame" ATG through nucleotide 35 of the first intron was replaced with a PGK-neomycin cassette in reverse orientation. This removes the splice donor site. Absence of transcript was confirmed by Northern blot analysis. (J:65881)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 8 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Spo11 Mutation:  21 strains or lines available
References
Original:  J:65881 Romanienko PJ, et al., The mouse spo11 gene is required for meiotic chromosome synapsis. Mol Cell. 2000 Nov;6(5):975-87
All:  19 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory