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Npy5rtm1Rpa
Targeted Allele Detail
Summary
Symbol: Npy5rtm1Rpa
Name: neuropeptide Y receptor Y5; targeted mutation 1, Richard D Palmiter
MGI ID: MGI:3028279
Synonyms: Y5R-
Gene: Npy5r  Location: Chr8:67132617-67140746 bp, - strand  Genetic Position: Chr8, 33.15 cM, cytoband B3-C2
Alliance: Npy5rtm1Rpa page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:87803
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: 760bp from the coding region were replaced with lacZ and a neomycin resistance gene. The replaced sequence included the translation initiation codon and sequence coding for the first 5 transmembrane spanning domains. RT-PCR indicated that less than 10% of normal transcript levels were present and this was most likely the consequence of read-through from the neomycin resistance gene rather than wild-type transcript. (J:87803)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Npy5r Mutation:  27 strains or lines available
References
Original:  J:87803 Marsh DJ, et al., Role of the Y5 neuropeptide Y receptor in feeding and obesity. Nat Med. 1998 Jun;4(6):718-21
All:  9 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory